Unfortunately we are unable to enroll everyone who wants to take part in the trial. In order to answer specific scientific questions, and to ensure the safety and well-being of our trial participants, we have to use a set of criteria against which people will be assessed for their eligibility. These criteria are specified below.
To be included in the trial participants must be:
1. Men and post-menopausal* women aged 55 years or over (at the point of database search)
2. On the stroke/TIA register of the general practice
*Post-menopausal is defined as: no menstrual period for 12 consecutive months or more.
The presence of any of the following will preclude participant inclusion:
1. Confirmed diagnosis of haemorrhagic stroke
2. Currently receiving treatment with more than the equivalent of 20 mg of atorvastatin
3. Currently receiving treatment with clopidogrel anti-platelet monotherapy
4. Currently receiving treatment with anti-coagulant therapy
5. Systolic blood pressure of less than 120mmHg
6. Orthostatic hypotension
7. Terminal illness
8. Known left ventricular systolic dysfunction (ejection fraction less than 30%)
9. Absolute contra-indication to atorvastatin, aspirin or ramipril or hypersensitivity to these components
10. Inability to give informed consent
11. Deemed unsuitable by GP for other reasons
12. Women of childbearing potential
13. Unable to swallow tablets or capsules.